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Human islets from Edmonton were provided by the Clinical Islet Transplant Program and by the Alberta Diabetes Institute Islet Core at the University of Alberta with the assistance of the Human Organ Procurement and Exchange (HOPE) program, Trillium Gift of Life Network (TGLN) and other Canadian organ procurement organizations

No weight-loss plateau at 52 weeks

Less-invasive options are preferred by many patients to preserve fertility

Topiramate reduces AMPA-induced Ca(2+) transients and inhibits GluR1 subunit phosphorylation in astrocytes from primary cultures

The Verdict: May offer supportive benefits for metabolism and satiety, but not a strong or direct GLP-1 booster

They follow a high-profile confrontation between the FDA and Hims & Hers Health, Inc